RET ligand-5
RET ligand-5 is a PROTAC target protein ligand that can be used for synthesis of PROTACs, such as PROTAC RET Degrader 1. PROTAC RET Degrader 1 is a potent RET PROTAC degrader with anti-tumor activity[1].
Product Specifications
CAS Number
2760853-48-1
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC; RET
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
CCC1(CCN(CC1)C2=NC=C(C=C2)C3=NC(Cl)=CN4N=CC(C#N)=C34)C(NC(C)C)=O
Molecular Formula
C23H26ClN7O
Molecular Weight
451.95
References & Citations
[1]Orsi DL, et al. Discovery of an orally bioavailable, CNS active pan-mutant RET kinase heterobifunctional degrader. RSC Med Chem. 2025 Aug 13. doi: 10.1039/d5md00337g. Epub ahead of print. PMID: 40823490; PMCID: PMC12352630.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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