RET ligand-5

RET ligand-5 is a PROTAC target protein ligand that can be used for synthesis of PROTACs, such as PROTAC RET Degrader 1 (HY-178964) . PROTAC RET Degrader 1 is a potent RET PROTAC degrader with anti-tumor activity[1].

Product Specifications

CAS Number

[2760853-48-1]

UNSPSC

12352005

Target

Ligands for Target Protein for PROTAC; RET

Related Pathways

PROTAC; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

CCC1(CCN(CC1)C2=NC=C(C=C2)C3=NC(Cl)=CN4N=CC(C#N)=C34)C(NC(C)C)=O

Molecular Formula

C23H26ClN7O

Molecular Weight

451.95

References & Citations

[1]Orsi DL, et al. Discovery of an orally bioavailable, CNS active pan-mutant RET kinase heterobifunctional degrader. RSC Med Chem. 2025 Aug 13. doi: 10.1039/d5md00337g. Epub ahead of print. PMID: 40823490; PMCID: PMC12352630.