E3 ligase Ligand 77
E3 ligase Ligand 77 is a CRBN type E3 ubiquitin ligase ligand. E3 ligase Ligand 77 can be used for synthesizing PROTAC, such as PROTAC RET Degrader 1 (HY-178964) [1].
Product Specifications
CAS Number
[2259850-62-7]
UNSPSC
12352005
Target
Ligands for E3 Ligase
Related Pathways
PROTAC
Field of Research
Cancer
Smiles
FC1=CC=CC(NC2CCC(NC2=O)=O)=C1
Molecular Formula
C11H11FN2O2
Molecular Weight
222.22
References & Citations
[1]Orsi DL, et al. Discovery of an orally bioavailable, CNS active pan-mutant RET kinase heterobifunctional degrader. RSC Med Chem. 2025 Aug 13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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