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Trans-Thalidomide-1,4-cyclohexanediamine

Trans-Thalidomide-1,4-cyclohexanediamine is a PROTAC E3 ligase-linker conjugate that can be used for synthesis of PROTACs, such as CL-F-B1. CL-F-B1 is a potent PD-L1 PROTAC degrader with anticancer activity[1].

Product Specifications

CAS Number

2983442-53-9

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C1N(C(C2=C(C=CC=C21)N[C@@H]3CC[C@@H](N)CC3)=O)C4CCC(NC4=O)=O

Molecular Formula

C19H22N4O4

Molecular Weight

370.40

References & Citations

[1]Qi Q, et al. Rational Design of PROTAC Degraders and Their Spatiotemporal Controlled Delivery for Enhanced Tumor Penetration and PD-L1 Protein Degradation. J Med Chem. 2025 Nov 13;68 (21) :22665-22688.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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