CL-F-B1
CL-F-B1 is a PD-L1 PROTAC degrader, with a DC50 of 2.32 μM. CL-F-B1 promotes the ubiquitination and degradation of PD-L1. CL-F-B1 can be used in the research of colon cancer[1].
Product Specifications
UNSPSC
12352005
Target
PD-1/PD-L1; PROTACs
Related Pathways
Immunology/Inflammation; PROTAC
Field of Research
Cancer
Smiles
O=C1N(C(C2=C(C=CC=C21)N[C@@H]3CC[C@@H](NC([C@@H](CO)NCC4=C(C=C(C(C)=C4)OCC5=CC=CC(C6=CC=C7OCCOC7=C6)=C5C)OCC8=CC(C#N)=CC=C8)=O)CC3)=O)C9CCC(NC9=O)=O
Molecular Formula
C54H54N6O10
Molecular Weight
947.04
References & Citations
[1]Qi Q, et al. Rational Design of PROTAC Degraders and Their Spatiotemporal Controlled Delivery for Enhanced Tumor Penetration and PD-L1 Protein Degradation. J Med Chem. 2025 Nov 13;68 (21) :22665-22688.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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