CL-F-B1

CL-F-B1 is a PD-L1 PROTAC degrader, with a DC50 of 2.32 μM. CL-F-B1 promotes the ubiquitination and degradation of PD-L1. CL-F-B1 can be used in the research of colon cancer[1].

Product Specifications

UNSPSC

12352005

Target

PD-1/PD-L1; PROTACs

Related Pathways

Immunology/Inflammation; PROTAC

Field of Research

Cancer

Smiles

O=C1N(C(C2=C(C=CC=C21)N[C@@H]3CC[C@@H](NC([C@@H](CO)NCC4=C(C=C(C(C)=C4)OCC5=CC=CC(C6=CC=C7OCCOC7=C6)=C5C)OCC8=CC(C#N)=CC=C8)=O)CC3)=O)C9CCC(NC9=O)=O

Molecular Formula

C54H54N6O10

Molecular Weight

947.04

References & Citations

[1]Qi Q, et al. Rational Design of PROTAC Degraders and Their Spatiotemporal Controlled Delivery for Enhanced Tumor Penetration and PD-L1 Protein Degradation. J Med Chem. 2025 Nov 13;68 (21) :22665-22688.