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KRAS-IN-48

KRAS-IN-48 (Compound 1-01) is a KRAS mutant inhibitor, with Kd values of 2.58 nM and 5.49 μM for KRAS-G12D and KRAS-G12V, respectively. KRAS-IN-48 can be used in the research of cancer[1].

Product Specifications

CAS Number

3074833-87-4

UNSPSC

12352005

Target

Ras

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Field of Research

Cancer

Smiles

OC=O.F[C@H](C1)CN(CCC2)[C@]12COC3=NC(N4CC5NC(CC5)C4)=C6N(C7CCC7)C(OC8=CC(O)=CC9=C8C(C#C)=C(F)C=C9)=NC6=N3.OC=O

Molecular Formula

C37H41F2N7O7

Molecular Weight

733.76

References & Citations

[1]Li X, et al. Imidazo Pyrimidine Compounds for the Inhibition of Oncogenic KRAS Mutations in Cancer Therapy. ACS Med Chem Lett. 2025 Oct 30;16 (11) :2194-2196.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

K-Ras

Frequently Asked Questions

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