POI ligand-2-NH-C10H20-NH-Boc
Selected Variant
HY-179299
Size: 1 Each
POI ligand-2-NH-C10H20-NH-Boc is a target protein ligand linker conjugate that contains a GPX4 ligand and a PROTAC linker (HY-W047688), which can recruit E3 ligases. POI ligand-2-NH-C10H20-NH-Boc can be used for synthesis of PROTAC GPX4 degrader-5 (HY-178925).
Product Specifications
UNSPSC
12352100
Target
Glutathione Peroxidase; Target Protein Ligand-Linker Conjugates
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; PROTAC
Field of Research
Cancer
Smiles
O=C(NCCC1=CC=CC=C1)C(C2=CC=CS2)N(C3=CC=C(C(Cl)=C3)OCC(NCCCCCCCCCCNC(OC(C)(C)C)=O)=O)C(C#C)=O
Molecular Formula
C40H51ClN4O6S
Molecular Weight
751.37
References & Citations
[1]Ning Y, et al. Design, synthesis, and biological evaluation of ML162-based glutathione peroxidase 4 (GPX4) degraders with hydrophobic tags. Eur J Med Chem. 2026 Jan 5;301:118269.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Price
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