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POI ligand-2

POI ligand-2 is a ligand for GPX4 protein. POI ligand-2 can be used to synthesize PROTAC, such as PROTAC GPX4 degrader-5.

Product Specifications

UNSPSC

12352100

Target

Glutathione Peroxidase; Ligands for Target Protein for PROTAC

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; PROTAC

Field of Research

Cancer

Smiles

ClC(C=C1N(C(C#C)=O)C(C(NCCC2=CC=CC=C2)=O)C3=CC=CS3)=C(C=C1)OCC(O)=O

Molecular Formula

C25H21ClN2O5S

Molecular Weight

496.96

References & Citations

[1]Ning Y, et al. Design, synthesis, and biological evaluation of ML162-based glutathione peroxidase 4 (GPX4) degraders with hydrophobic tags. Eur J Med Chem. 2026 Jan 5;301:118269.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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