POI ligand-2
POI ligand-2 is a ligand for GPX4 protein. POI ligand-2 can be used to synthesize PROTAC, such as PROTAC GPX4 degrader-5 (HY-178925) [1].
Product Specifications
UNSPSC
12352100
Target
Glutathione Peroxidase; Ligands for Target Protein for PROTAC
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; PROTAC
Field of Research
Cancer
Smiles
ClC(C=C1N(C(C#C)=O)C(C(NCCC2=CC=CC=C2)=O)C3=CC=CS3)=C(C=C1)OCC(O)=O
Molecular Formula
C25H21ClN2O5S
Molecular Weight
496.96
References & Citations
[1]Ning Y, et al. Design, synthesis, and biological evaluation of ML162-based glutathione peroxidase 4 (GPX4) degraders with hydrophobic tags. Eur J Med Chem. 2026 Jan 5;301:118269.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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