ZLY025
ZLY025 is a potent and orally active CCNK molecular glue degrader with an DC50 of 42.7 nM. ZLY025 exhibits broad-spectrum antiproliferative activity against various tumor cells with IC50 values ranging from 0.08 to 2.45 μM. ZLY025 can induce cells apoptosis and G1 phase arrest. ZLY025 can be used for the research of cancer, such as lung cancer[1].
Product Specifications
CAS Number
3070379-34-6
UNSPSC
12352005
Target
Apoptosis; CDK; Molecular Glues
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
CC1=CN=C(NC(CC2=CC=C(C=C2)C3=NC=CO3)=O)S1
Molecular Formula
C15H13N3O2S
Molecular Weight
299.35
References & Citations
[1]Liu Y, et al. Discovery of Highly Potent and Orally Available CCNK Molecular Glue Degraders as Broad-Spectrum Antitumor Agents. J Med Chem. 2025;68 (21) :22689-22714.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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