PTP1B-IN-32

PTP1B-IN-32 (Compound 5G) is an uncompetitive PTP1B inhibitor, with a Ki value of 0.72 μM. PTP1B-IN-32 enhances insulin sensitivity. PTP1B-IN-32 can be used in the research of diabetes[1].

Product Specifications

CAS Number

[2701546-87-2]

UNSPSC

12352005

Target

Phosphatase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Smiles

C[C@]1(C(O)=O)CC[C@@]2(C)[C@@](C([C@@]3(C)CC2)=CC([C@@]4([H])[C@@]3(C)CC[C@]5([H])[C@]4(C)CC(C=NN6C7=CC=C(S(=O)(N)=O)C=C7)=C6C5(C)C)=O)([H])C1

Molecular Formula

C37H49N3O5S

Molecular Weight

647.87

References & Citations

[1]López-Sánchez M, et al. Optimization of Indole-and Pyrazole-fused Glycyrrhetinic Acid Derivatives as Potent PTP1B Inhibitors: In Silico, In Vitro, In Vivo, and Metabolomic Studies[J]. ACS Bio & Med Chem Au, 2025.