PROTAC SARS-CoV-2 RdRp Degrader-1

PROTAC SARS-CoV-2 RdRp Degrader-1 (PROTAC 10) is a SARS-CoV-2 RdRp PROTAC degrader, with a DC50 of 1.97 μM (in infected cells) . PROTAC SARS-CoV-2 RdRp Degrader-1 promotes the ubiquitination and degradation of SARS-CoV-2 RdRp. PROTAC SARS-CoV-2 RdRp Degrader-1 can be used in the research of SARS-CoV-2 infection[1].

Product Specifications

UNSPSC

12352005

Target

PROTACs; SARS-CoV

Related Pathways

Anti-infection; PROTAC

Field of Research

Infection

Smiles

O[C@H]1[C@@H](O)[C@H](N2C(N=C(C=C2)NO)=O)O[C@@H]1COC(CCCCCN(N=N3)C=C3CCOC4=CC(C(N5[C@H](C(N6)=O)CCC6=O)=O)=C(C5=O)C=C4)=O

Molecular Formula

C32H36N8O12

Molecular Weight

724.67

References & Citations

[1]Shehzadi K, et al. Structure-Informed Design of High-Cooperativity PROTAC Targeting SARS-CoV-2 RdRp via Click Chemistry and Enhanced Sampling Simulations. J Med Chem. 2025 Nov 13;68 (21) :23247-23266.