LXR agonist 4
LXR agonist 4 is a selective LXR inverse agonist with IC50 values of 7.6 (LXRα) and 2.9 μM (LXRβ), respectively. LXR agonist 4 exhibits selectivity over RORα and FXR. LXR agonist 4 robustly suppresses SREBP1c expression without altering ABCA1 or APOE. LXR agonist 4 displays antilipogenic properties and resolves fatty acid-induced steatosis. LXR agonist 4 can be used for the research of atherosclerosis and metabolic dysfunction-associated steatotic liver disease (MASLD) [1].
Product Specifications
UNSPSC
12352100
Target
LXR
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Endocrinology; Metabolic Disease; Cardiovascular Disease
Smiles
CS(C1=CC=CC(C2=CC=C(C=C2)CN(CC(C3=CC=CC=C3)C4=CC=CC=C4)CC5=CC=CC(C(F)(F)F)=C5Cl)=C1)(=O)=O
Molecular Formula
C36H31ClF3NO2S
Molecular Weight
634.15
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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