Wee1/HDAC-IN-1

Wee1/HDAC-IN-1 is a  dual Wee1/HDAC inhibitor with an IC50 of 1.2 nM for Wee1 and IC50 values of 196 nM for HDAC1, 156 nM for HDAC3, and 55 nM for HDAC6. Wee1/HDAC-IN-1 exhibits strong antiproliferative activity against MV4-11 cells with an IC50 of 0.076 μM. Wee1/HDAC-IN-1 selectively binds to Wee1 and HDACs. Wee1/HDAC-IN-1 interferes with DNA damage repair pathways and induces apoptosis in MV4-11 cells.  Wee1/HDAC-IN-1  Wee1/HDAC-IN-1 can be used for the research of acute myeloid leukemia (AML) [1].

Product Specifications

CAS Number

[3037071-29-4]

UNSPSC

12352005

Target

Apoptosis; HDAC; Wee1

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C1N(N(C2=NC(NC3=CC=C(C=C3)N4CCN(CC4)CCCCCCC(NO)=O)=NC=C21)C5=NC(C(O)(C)C)=CC=C5)CC=C

Molecular Formula

C33H43N9O4

Molecular Weight

629.75

References & Citations

[1]Zhang W, et al. Discovery of Novel and Highly Potent Wee1 and HDAC Dual-Target Inhibitors for the Treatment of Acute Myeloid Leukemia. J Med Chem. 2025;68 (21) :22845-22873.