CA/HDAC-IN-1

CA/HDAC-IN-1 (Compound 11) is a CA and HDAC inhibitor with Ki values of 7.4 nM, 31.0 nM, and 7.3 nM for hCA II, hCA IX, and hCA XII, respectively, and IC50 values of 0.21 μM and 3.60 μM for HDAC3 and HDAC8, respectively. CA/HDAC-IN-1 has anti-cancer activity against colon cancer, breast cancer, and melanoma[1].

Product Specifications

UNSPSC

12352005

Target

Carbonic Anhydrase; HDAC

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

O=C(NC1=CC=CC=C1N)C2=CC=C(CNC(NC3=CC=C(S(=O)(N)=O)C=C3)=O)C=C2

Molecular Formula

C21H21N5O4S

Molecular Weight

439.49

References & Citations

[1]Bozdag M, et al. Discovery of First-in-Class Carbonic Anhydrase/Histone Deacetylase Dual Inhibitors with Antiproliferative Activity in Cancer Cells. J Med Chem. 2025 Nov 13;68 (21) :22874-22895.