DNPH1-IN-1
DNPH1-IN-1 (Compound 38) is a potent, cell-active non-nucleoside DNPH1 inhibitor, with a pIC50 of 9.3. DNPH1-IN-1 increases DNA-bound hmdU. DNPH1-IN-1 can be used in the research of breast cancer[1].
Product Specifications
UNSPSC
12352005
Target
Glycosidase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C(C1=CC(C2=CC=CC(C(F)(F)F)=C2F)=C(NC3=NC(N[C@@H]4CN(C5=CN=CN=C5)CC4)=C6C=C(C)C=CC6=N3)C=C1)O
Molecular Formula
C31H25F4N7O2
Molecular Weight
603.57
References & Citations
[1]Barlaam B, et al. Discovery and Optimization of a Non-Nucleoside-Based Series of Inhibitors of 2'-Deoxynucleoside 5'-Monophosphate Glycosidase (DNPH1) . J Med Chem. 2025 Nov 27;68 (22) :24381-24403.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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