DNPH1-IN-1

DNPH1-IN-1 (Compound 38) is a potent, cell-active non-nucleoside DNPH1 inhibitor, with a pIC50 of 9.3. DNPH1-IN-1 increases DNA-bound hmdU. DNPH1-IN-1 can be used in the research of breast cancer[1].

Product Specifications

UNSPSC

12352005

Target

Glycosidase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

O=C(C1=CC(C2=CC=CC(C(F)(F)F)=C2F)=C(NC3=NC(N[C@@H]4CN(C5=CN=CN=C5)CC4)=C6C=C(C)C=CC6=N3)C=C1)O

Molecular Formula

C31H25F4N7O2

Molecular Weight

603.57

References & Citations

[1]Barlaam B, et al. Discovery and Optimization of a Non-Nucleoside-Based Series of Inhibitors of 2'-Deoxynucleoside 5'-Monophosphate Glycosidase (DNPH1) . J Med Chem. 2025 Nov 27;68 (22) :24381-24403.