FTO-IN-15

FTO-IN-15 (Compound 8a) is a potent and selective dual-competitive FTO inhibitor with an IC50 of 43.7 nM, showing high selectivity over ALKBH3 and ALKBH5. FTO-IN-15 substantially inhibits FTO demethylation by simultaneously occupying the substrate and 2-oxoglutarate (2-OG) pockets. FTO-IN-15 can be used for the research of acute myeloid leukemia (AML) [1].

Product Specifications

UNSPSC

12352005

Target

Fat Mass and Obesity-associated Protein (FTO)

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(/C=C/C(NCCNC(C1=CC(Cl)=C(C(Cl)=C1)NC2=CC=CC=C2C(O)=O)=O)=O)O

Molecular Formula

C20H17Cl2N3O6

Molecular Weight

466.27

References & Citations

[1]Zhang X, et al. Structure-Based Design of a Highly Potent Dual-Competitive FTO Inhibitor for Targeted m6A Demethylase Inhibition in AML. J Med Chem. 2025 Nov 13;68 (21) :22779-22798.