BDGR-651
BDGR-651 is an efficient and selective inhibitor of the Chikungunya virus (CHIKV) with an EC50 in NHDF cells of 0.86 μM, and the therapeutic index (SI) of 22.1. BDGR-651 exhibits dose-dependent protective effects when infecting Vero E6 cells, with its EC50 being 6 μM. BDGR-651 can be used for research on CHIKV infection[1].
Product Specifications
UNSPSC
12352005
Target
CHIKV
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
O=C1N(C2=CC(F)=C(OC)C(F)=C2)C([C@@H]3NCCCC3)=NC4=C1C=C(Cl)C(N5CCN(C(C)C)CC5)=C4
Molecular Formula
C27H32ClF2N5O2
Molecular Weight
532.03
References & Citations
[1]Roach CM, et al. Restructuring Antiviral Quinazolinone Frameworks to Derive and Optimize Inhibitors of Chikungunya Virus. ACS Med Chem Lett. 2025 Oct 24;16 (11) :2320-2327.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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