Fluoroneplanocin A-8N
Fluoroneplanocin A-8N (Compound 3a) is an inhibitor targeting SAH hydrolase (IC50 = 1.51 μM) and viral RNA polymerase. Fluoroneplanocin A-8N exhibits broad-spectrum anti-SARS-CoV-2 and dengue virus activity, with EC50 values of 12.2 and 37.4 μM respectively. Fluoroneplanocin A-8N has no cytotoxicity. Fluoroneplanocin A-8N can be used for anti-positive-strand viruses[1].
Product Specifications
UNSPSC
12352005
Target
Dengue Virus; DNA/RNA Synthesis; Nucleoside Antimetabolite/Analog; SARS-CoV
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Field of Research
Infection
Smiles
O[C@@H]1[C@H](O)C(CO)=C(F)[C@H]1N2N=NC3=C(N)N=CN=C32
Molecular Formula
C10H11FN6O3
Molecular Weight
282.23
References & Citations
[1]Song J, et al. Design, Synthesis, and Antiviral Activity of 8‑Aza Fluoroneplanocin Derivatives Targeting SAH Hydrolase and Viral RdRp. ACS Med Chem Lett. 2025 Oct 21;16 (11) :2248-2256.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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