Adenosine receptor antagonist 7
Adenosine receptor antagonist 7 is an orally active triple A1/A2A/A2B adenosine receptor antagonist with Ki values of 1.5, 0.6 and 21 nM. Adenosine receptor antagonist 7 shows potent inhibitory activity (IC50 = 0.8 nM) of cAMP production in A2AR-HEK293 cells. Adenosine receptor antagonist 7 can enhance infiltration of effector T cells and increase the CD8+/Treg ratio companied with Avelumab (HY-108730) . Adenosine receptor antagonist 7can be used for the research of cancer, such as colon cancer[1].
Product Specifications
CAS Number
[2570904-69-5]
UNSPSC
12352005
Target
Adenosine Receptor; ERK; JNK; MMP
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
NC1=NC(N2C=CN=C2)=C(C(C3=CC(N4CC[C@H](C4)OC)=CC(OC)=C3)=C1)C#N
Molecular Formula
C21H22N6O2
Molecular Weight
390.44
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Adenosine A1 receptor (A1R) ; Adenosine A2A receptor (A2AR) ; Adenosine A2B receptor (A2BR) ; MMP-2; MMP-8; MMP-9
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