S3D5
S3D5 is a highly efficient and selective PROTAC degrader targeting STAT3 (KD = 4.35 μM) . S3D5 induces degradation of STAT3 in HepG2 cells without significant effects on other STAT proteins. S3D5 exhibits good anti-hepatocellular carcinoma cell proliferation activity, which can be explained by activating the p53 pathway. S3D5 degradation of the STAT3 protein is mediated by the ubiquitin–proteasome system (UPS) . S3D5 can be used for the study of hepatocellular carcinoma[1].
Product Specifications
CAS Number
3033746-21-0
UNSPSC
12352005
Target
MDM-2/p53; PROTACs; STAT
Related Pathways
Apoptosis; JAK/STAT Signaling; PROTAC; Stem Cell/Wnt
Field of Research
Cancer
Smiles
CN(S(=O)(C1=C(C(F)=C(C(F)=C1F)F)F)=O)CC(NC2=CC=C(C=C2)C(NCCOCCOCCOCCOCCOCCNC3=C4C(C(N(C5C(NC(CC5)=O)=O)C4=O)=O)=CC=C3)=O)=O
Molecular Formula
C41H45F5N6O13S
Molecular Weight
956.89
References & Citations
[1]Wang K, et al. Discovery of a potent and selective PROTAC degrader for STAT3. RSC Med Chem. 2025 Jul 31.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT3
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