UNC10062
UNC10062 is a dopamine D1 receptor (D1R) positive allosteric modulator. UNC10062 specifically binds to the extracellular allosteric pocket (upper pocket) at the interface of transmembrane helices (TM) 1 and 7 of D1R. UNC10062 can increase dopamine potency and D1R-mediated cAMP production. UNC10062 can be used for the research of neurological disease, such as Parkinson's disease[1].
Product Specifications
UNSPSC
12352100
Target
Dopamine Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
CC(C)(C1CCC2=C(SC(NC(C3=CC=NC=C3)=O)=C2C(N)=O)C1)C(OC)=O
Molecular Formula
C20H23N3O4S
Molecular Weight
401.48
References & Citations
[1]Wang K, et al. Multiple Allosteric Sites Allow for Synergistic Enhancement of GPCR Signaling. bioRxiv [Preprint]. 2025 Oct 22:2025.10.21.683604.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D1 Receptor
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