METTL3-IN-12
METTL3-IN-12 (Compound 15) is a selective METTL3 inhibitor with an IC50 of 50 nM. METTL3-IN-12 exhibits significant anti-proliferative activity in various leukemia cell lines. METTL3-IN-12 can be used for research on leukemia[1].
Product Specifications
UNSPSC
12352005
Target
METTL3
Related Pathways
Epigenetics
Field of Research
Cancer
Smiles
O=C1C=C(C2=CC=CC3=C2C=NN3)C=CN1CC4=CC5=C(C=C4)C=C(CNCC6CCCCC6)N5
Molecular Formula
C29H31N5O
Molecular Weight
465.59
References & Citations
[1]Zhang W, et al. Discovery of Novel Class of METTL3 Inhibitors with a Pyridin-2 (1H) ‑one Moiety. ACS Med Chem Lett. 2025 Nov 4;16 (11) :2257-2263.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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