CS-1-103
CS-1-103 is a potent estrogen receptor (ER) inhibitor. CS-1-103 inhibits ER transcriptional activity with an EC50 of 0.36 μM by recruiting methyl-CpG binding domain protein 2 (MBD2), HDACs and the nucleosome remodeling and deacetylase (NuRD) complex. CS-1-103 can be used for breast and prostate cancer research[1].
Product Specifications
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
OC1=CC=C2C(CCC3C2CC[C@@]4(C)C3CC/C4=N\OCC(NCCCCCCNC(C5=CC=CC(NC6=NC(C7=NC=CC=C7)=CS6)=C5)=O)=O)=C1
Molecular Formula
C41H48N6O4S
Molecular Weight
720.92
References & Citations
[1]Stieger CE, et al. Targeted Transcriptional Repression by Induced Proximity. bioRxiv [Preprint]. 2025 Oct 22:2025.10.22.680877.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Estrogen receptor
Frequently Asked Questions
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