MK2-IN-8
MK2-IN-8 (Compound 42) is a covalent MK2 kinase inhibitor. MK2-IN-8 forms a unique covalent bond with the catalytic lysine, thereby demonstrating that the fluorosulfonate can effectively target the catalytic lysine in kinases.
Product Specifications
UNSPSC
12352005
Target
MAPKAPK2 (MK2)
Related Pathways
MAPK/ERK Pathway
Field of Research
Others
Smiles
O=C(C1=CC=C(C2=CC(OS(=O)(F)=O)=C(Cl)C=C2)O1)N(CC3=NC=CC=C3)C4=CC=C(N5CCNCC5)C=C4
Molecular Formula
C27H24ClFN4O5S
Molecular Weight
571.02
References & Citations
[1]Hillebrand L, et al. A twist in the tale: shifting from covalent targeting of a tyrosine in JAK3 to a lysine in MK2. RSC Med Chem. 2025 Aug 1;16 (10) :4906-4919.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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