PROTAC STAT6 degrader-2

PROTAC STAT6 degrader-2 is a highly efficient PROTAC degrader targeting STAT6. PROTAC STAT6 degrader-2 has a DC50 value of 1-10 nM for STAT6 in human PBMC cells and a DC50 value of less than 100 nM for STAT6 in HEK293-HIBiT-STAT6 cells. PROTAC STAT6 degrader-2 can be used for STAT6-mediated diseases[1].

Product Specifications

CAS Number

[3105288-31-8]

UNSPSC

12352005

Target

PROTACs; STAT

Related Pathways

JAK/STAT Signaling; PROTAC; Stem Cell/Wnt

Field of Research

Cancer

Smiles

N#C[C@@H]1CN(C([C@H]2N(C([C@@H](NC(C3=CC4=C(C=CC(C(P(O)(O)=O)(F)F)=C4)S3)=O)CN(C(CC5CCN(C6=C(N(C)C(N7C8C(NC(CC8)=O)=O)=O)C7=CC=C6)CC5)=O)CC9)=O)[C@]9([H])CC2)=O)C[C@H]1C%10=CC=CC=C%10

Molecular Formula

C51H54F2N9O10PS

Molecular Weight

1054.06

References & Citations

[1]Stat6-selective degrader compound and use thereof. WO2025218706 A1. Gu, Peng, et al.|[2]Lu D, et al. Design, Optimization, and Development of RIPK1 Degraders with Improved Pharmacokinetic and Pharmacodynamic Properties. J Med Chem. 2025 Nov 13;68 (21) :22246-22263.