ERα antagonist 2
ERα antagonist 2 (Compound 5b) is an ER-α antagonist with an IC50 value of 1729 nM. ERα antagonist 2 exhibits significant inhibitory activity against breast cancer cell lines, and is still effective against ER-negative cells (MDA-MB-231), suggesting the existence of ER-independent pathways. ERα antagonist 2 can be used for the study of breast cancer[1].
Product Specifications
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
CC(C=C1)=CC=C1S(N(C(C2=CN(CC3=CC=CC=C3)C4=C2C=CC=C4)=NN5S(C6=CC=C(C)C=C6)(=O)=O)N=C5C7=CN(C8=C7C=CC=C8)CC9=CC=CC=C9)(=O)=O
Molecular Formula
C46H38N6O4S2
Molecular Weight
802.96
References & Citations
[1]Kaur K, et al. Design, synthesis and biological evaluation of novel bis (indolyl) -tetrazine derivatives as anti-breast cancer agents. RSC Med Chem. 2025 Jul 23.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERα
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