E3 Ligase Ligand-linker Conjugate 214

E3 Ligase Ligand-linker Conjugate 214 is an E3 ligase ligand-linker conjugate containing a Von Hippel-Lindau (VHL) ligand and a linker. E3 Ligase Ligand-linker Conjugate 214 can bind to a target protein ligand to form a PROTAC molecule, PROTAC LSD1 Degrader 1 (HY-179229) [1].

Product Specifications

CAS Number

[2451247-91-7]

UNSPSC

12352005

Target

PROTAC-Linker Conjugates for PAC

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Field of Research

Cancer

Smiles

CC1=C(SC=N1)C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCCCCCCCCCCN)=O)=O)O)=O

Molecular Formula

C34H53N5O4S

Molecular Weight

627.88

References & Citations

[1]Coulson ME, et al. Synthetic and structure-activity studies of SP2577 and TCP towards LSD1 targeting PROTACs. RSC Med Chem. 2025 Aug 5;16 (10) :4952-4959.