LSD1-IN-47

LSD1-IN-47 is a highly efficient PROTAC degrader targeting LSD1 (IC50 = 43 nM) . LSD1-IN-47 does not alter LSD1 protein levels and does not increase the histone marker H3K4me2. LSD1-IN-47 can be used for the study of colon carcinoma[1].

Product Specifications

UNSPSC

12352005

Target

Histone Demethylase; PROTACs

Related Pathways

Epigenetics; PROTAC

Field of Research

Cancer

Smiles

CC1=C(SC=N1)C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCCCCCCCCCCNC(C4=CC=C([C@H]5[C@H](N)C5)C=C4)=O)=O)=O)O)=O

Molecular Formula

C44H62N6O5S

Molecular Weight

787.07

References & Citations

[1]Coulson ME, et al. Synthetic and structure-activity studies of SP2577 and TCP towards LSD1 targeting PROTACs. RSC Med Chem. 2025 Aug 5;16 (10) :4952-4959.