AN02
AN02 is a derivative of Curcumin. AN02 inhibits the proliferation and clonogenicity, migration and invasion of ovarian cancer cells. AN02 dose-dependently upregulates the expression of APC and mediates the degradation of CTLA-4 through SMAD4. In the small xenograft model, AN02 significantly inhibits tumor growth and reverses the tumor immune-suppressive microenvironment. AN02, when combined with Ipilimumab (HY-P9901), can enhance efficacy and inhibit epithelial-mesenchymal transition. AN02 can be used for the study of ovarian cancer[1].
Product Specifications
CAS Number
1246964-08-8
UNSPSC
12352005
Target
CTLA-4; TGF-beta/Smad
Related Pathways
Immunology/Inflammation; Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Cancer
Smiles
ClC1=CC=CC=C1/C=C(C/2=O)\CNCC2=C/C3=C(Cl)C=CC=C3
Molecular Formula
C19H15Cl2NO
Molecular Weight
344.23
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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