AP-7-168
AP-7-168, molecular glues, is a β-arrestin-biased negative allosteric modulator of the β2-adrenergic receptor (β2AR) . AP-7-168 can promote β2AR homodimerization and inhibit GRK5-mediated β2AR phosphorylation. AP-7-168 can sustain bronchorelaxation in cell and tissue. AP-7-168 can be used for the researches of inflammation and immunology, such as asthma[1].
Product Specifications
CAS Number
2816062-15-2
UNSPSC
12352005
Target
Adrenergic Receptor; Molecular Glues
Related Pathways
GPCR/G Protein; Neuronal Signaling; PROTAC
Field of Research
Inflammation/Immunology
Smiles
FC1=C(C=C(C=C1)NC2=NC3=CC=C(C=C3C(NC4CCCCC4)=N2)Br)F
Molecular Formula
C20H19BrF2N4
Molecular Weight
433.29
References & Citations
[1]Jiemin Shen, et al. A biased allosteric modulator functions as a molecular glue to induce β2AR dimerization. bioRxiv. October 22, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
β adrenergic receptor
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