HIV-1-IN-88

HIV-1-IN-88 (compound 20a) is a potent HIV‑1 protease inhibitor (IC50 = 10 pM) with an antiviral EC50 of 10.4 nM. HIV-1-IN-88 exhibits potency against the multidrug-resistant variants HIV-1Muta and HIV-1I50V with EC50 values of 30.0 and 34.3 nM, respectively. HIV-1-IN-88 can be used for HIV research[1].

Product Specifications

CAS Number

[2459707-59-4]

UNSPSC

12352005

Target

HIV; HIV Protease

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Infection

Smiles

O[C@@H]([C@@H](NC([C@H](CC(N)=O)NC(O[C@@]1([C@]2([C@@]([H])(OC1)OCC2)[H])[H])=O)=O)CC3=CC=CC=C3)CN(CC(C)C)S(=O)(C4=CC=C(C=C4)OC)=O

Molecular Formula

C32H44N4O10S

Molecular Weight

676.78

References & Citations

[1]Zhou H, et al. Design, Synthesis, and Biological Evaluation of Novel Core Scaffold-Modified HIV-1 Protease Inhibitors for Overcoming Drug Resistance. J Med Chem. 2025 Nov 13;68 (21) :22547-22568.