DAA
DAA is a potent autophagy inducer that exhibits antitumor efficacy and enhances anti-PD1 immunotherapy in non-small cell lung cancer (NSCLC) . DAA acts by disrupting the LIC1-RuvB-like AAA ATPase 1 interaction, which activates the GCN2-eIF2α-ATF4 integrated stress response pathway and promotes autophagic cell death. DAA can be used for NSCLC research[1].
Product Specifications
UNSPSC
12352005
Target
Autophagy
Related Pathways
Autophagy
Field of Research
Cancer
Smiles
COC1=CC(O)=C(C([C@]2([C@H](OC(C(C)C)=O)[C@H](OC(C(C)C)=O)[C@](O)(C)C3)[C@@]3(O2)C4=O)=O)C4=C1
Molecular Formula
C24H28O10
Molecular Weight
476.47
References & Citations
[1]Huang JL, et al. A small molecule targets LIC1 to suppress lung tumor growth by inducing autophagy. Nat Chem Biol. 2025 Oct 16.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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