ATX020

ATX020 is a potent, selective and orally active kinesin KIF18A inhibitor. ATX020 inhibits the ATPase activity of KIF18A in humans, rats and dogs, with IC50 values of 0.11 μM, 0.16 μM and 0.24 μM, respectively. ATX020 shows high selectivity for other motor proteins (CENP-E, Eg5, KIF15, etc.), with IC50 values >10 μM and only has a weak inhibitory effect on KIF19 (IC50 = 6.1 μM) . ATX020 can inhibit cancer cells proliferation[1].

Product Specifications

CAS Number

[3030452-08-2]

UNSPSC

12352005

Target

Kinesin

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(NC1=NC(C2CCC(F)(F)CC2)=NC(C)=C1)C3=CC=C(NS(=O)(CCO)=O)C=C3N4CC[Si](C)(C)CC4

Molecular Formula

C26H37F2N5O4SSi

Molecular Weight

581.75

References & Citations

[1]Sparling BA, et al. Discovery of Kinesin KIF18A Inhibitor ATX020: Tactical Application of Silicon Atom Replacement. ACS Med Chem Lett. 2025 Oct 27;16 (11) :2309-2319.