ATX020
ATX020 is a potent, selective and orally active kinesin KIF18A inhibitor. ATX020 inhibits the ATPase activity of KIF18A in humans, rats and dogs, with IC50 values of 0.11 μM, 0.16 μM and 0.24 μM, respectively. ATX020 shows high selectivity for other motor proteins (CENP-E, Eg5, KIF15, etc.), with IC50 values >10 μM and only has a weak inhibitory effect on KIF19 (IC50 = 6.1 μM) . ATX020 can inhibit cancer cells proliferation[1].
Product Specifications
CAS Number
3030452-08-2
UNSPSC
12352005
Target
Kinesin
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(NC1=NC(C2CCC(F)(F)CC2)=NC(C)=C1)C3=CC=C(NS(=O)(CCO)=O)C=C3N4CC[Si](C)(C)CC4
Molecular Formula
C26H37F2N5O4SSi
Molecular Weight
581.75
References & Citations
[1]Sparling BA, et al. Discovery of Kinesin KIF18A Inhibitor ATX020: Tactical Application of Silicon Atom Replacement. ACS Med Chem Lett. 2025 Oct 27;16 (11) :2309-2319.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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