AO-365/43472821
AO-365/43472821 is a selective, brain-penetrant Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitor (IC50 = 0.29 μM) and shows a significant inhibitory effect on (CDC-like kinase 1) CLK1 (IC50 = 0.08 μM) . AO-365/43472821 could protect the human neuroblastoma cell line SH-SY5Y from Okadaic acid (HY-N6785) (OA) -induced injury. AO-365/43472821 decreased tau (pSer396) /tau and Aβ1-42 protein expression. AO-365/43472821 can be used for the study of Alzheimer's disease[1].
Product Specifications
CAS Number
[1081122-55-5]
UNSPSC
12352005
Target
Amyloid-β; CDK; DYRK; Tau Protein
Related Pathways
Cell Cycle/DNA Damage; Neuronal Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Neurological Disease
Smiles
COC1=CC=CC=C1OCC2=NN3C(COC4=CC5=C(OCO5)C=C4)=NN=C3S2
Molecular Formula
C19H16N4O5S
Molecular Weight
412.42
References & Citations
[1]Si X, et al. Computer-aided discovery of triazolothiadiazoles as DYRK1A-targeted neuroprotective agents. RSC Med Chem. 2025 Jul 14.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CLK; DYRK1
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