SEH-H ligand 2

SEH-H ligand 2 is an sEH inhibitor and a ligand for the target protein for PROTAC (sEH) . sEH-H ligand 2 can be used to synthesize PROTAC sEH-degrader-4 (HY-179166) [1].

Product Specifications

UNSPSC

12352005

Target

Epoxide Hydrolase; Ligands for Target Protein for PROTAC

Related Pathways

Metabolic Enzyme/Protease; PROTAC

Field of Research

Inflammation/Immunology

Smiles

O=C(NCCCC#C)C1=CC=C(O[C@H]2CC[C@H](NC(NC3=CC=C(OC(F)(F)F)C=C3)=O)CC2)C=C1

Molecular Formula

C26H28F3N3O4

Molecular Weight

503.51

References & Citations

[1]Schönfeld J, et al. Click chemistry enables rapid development of potent sEH PROTACs using a direct-to-biology approach. Chem Commun (Camb) . 2025 Nov 13;61 (92) :18108-18111.