Gαq/11 protein-IN-2

Gαq/11 protein-IN-2 (Compound 9g) is a Gαq/11 protein inhibitor, with an IC50 of 11.3 μM. Gαq/11 protein-IN-2 induces Apoptosis, increases p-YAP. Gαq/11 protein-IN-2 has anticancer activity against uveal melanoma[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; P2Y Receptor; YAP

Related Pathways

Apoptosis; GPCR/G Protein; Stem Cell/Wnt

Field of Research

Cancer

Smiles

CCCCC(N1)=NC2=C1C(CC3CCCCC3)N(C([C@@H](N)[C@@H](C)CC)=O)CC2

Molecular Formula

C23H40N4O

Molecular Weight

388.59

References & Citations

[1]Hu Q L, et al. Chemoselective Minisci alkylation in aqueous medium: a general strategy for functionalization of complex N-heteroarenes and biomolecules. Green Chemistry, 2025.