CDK2-IN-49
CDK2-IN-49 (Compound 5j) is a CDK2 inhibitor with an IC50 of 0.25 μM. CDK2-IN-49 shows potent activity against CDK7 with an IC50 of 0.14 μM. CDK2-IN-49 induces Apoptosis by raising the levels of p53 and Bax protein expression while reducing the amount of Bcl-2. CDK2-IN-49 inhibits cell division. CDK2-IN-49 can be used in the research of cancer[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; CDK; MDM-2/p53
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
COC1=CC=C(C=C1)/N=N/C2=C3N=CC=C(N3N=C2N)C4=CC=C(C=C4)C
Molecular Formula
C20H18N6O
Molecular Weight
358.40
References & Citations
[1]Elbakry O M, et al. Targeting CDK2 and CDK7: rational design of pyrazolo [1, 5-a] pyrimidine derivatives as potent anticancer agents. New Journal of Chemistry, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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