CDK2-IN-49

CDK2-IN-49 (Compound 5j) is a CDK2 inhibitor with an IC50 of 0.25 μM. CDK2-IN-49 shows potent activity against CDK7 with an IC50 of 0.14 μM. CDK2-IN-49 induces Apoptosis by raising the levels of p53 and Bax protein expression while reducing the amount of Bcl-2. CDK2-IN-49 inhibits cell division. CDK2-IN-49 can be used in the research of cancer[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Bcl-2 Family; CDK; MDM-2/p53

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

COC1=CC=C(C=C1)/N=N/C2=C3N=CC=C(N3N=C2N)C4=CC=C(C=C4)C

Molecular Formula

C20H18N6O

Molecular Weight

358.40

References & Citations

[1]Elbakry O M, et al. Targeting CDK2 and CDK7: rational design of pyrazolo [1, 5-a] pyrimidine derivatives as potent anticancer agents. New Journal of Chemistry, 2025.