Tubulin-IN-61

Tubulin-IN-61 is a tubulin polymerization inhibitor with an IC50 of ≤7.63 μM. Tubulin-IN-61 induces early apoptosis and triggers significant G2/M phase arrest. Tubulin-IN-61 elevates intracellular ROS levels. Tubulin-IN-61 shows high activity against MCF-7 cells with an IC50 of 5.61 μM. Tubulin-IN-61 can be used for the research of breast cancer[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Microtubule/Tubulin; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

COC1=CC(C2=NC3=C(C=CC=C3)N2CC4=CN(N=N4)CC5=CC6=C(C(C7=CC=CS7)=N5)NC8=CC=CC=C86)=CC=C1OC

Molecular Formula

C34H27N7O2S

Molecular Weight

597.69

References & Citations

[1]Mursalim Ali Khan, et al. Design, synthesis, and cytotoxicity evaluation of 1,2,3-triazole-linked β-carboline-benzimidazole hybrids as tubulin polymerization inhibitors. New J. Chem., 2025,49, 17716-17729.