MA203

MA203 is a highly efficient and selective PROTAC degrader targeting CHK1. MA203 accelerates CRBN-dependent proteasomal degradation of CHK1 in solid tumor-derived cells and acute leukemia cells. MA203 induces DNA replication stress. MA203 blocks cell cycle progression and triggers tumor cell apoptosis. MA203 does not damage healthy differentiated and primitive hematopoietic cells, stromal cells, and retinal epithelial cells. MA203 can be used for the study of CHK1-dependent cancers[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Bcl-2 Family; Caspase; Checkpoint Kinase (Chk) ; DNA/RNA Synthesis; PROTACs

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; PROTAC

Field of Research

Cancer

Smiles

O=C1CCC(N2C(C(C=CC=C3NCCCCCCCNC(C4=CC(OC[C@H]5OCCNC5)=C(NC(NC6=CN=C(C)C=N6)=O)C=C4)=O)=C3C2=O)=O)C(N1)=O

Molecular Formula

C38H45N9O8

Molecular Weight

755.82

References & Citations

[1]Ashry R, et al. Identification of a Proteolysis-Targeting-Chimera that Addresses Activated Checkpoint Kinase-1 Reveals its Non-Catalytic Functions in Tumor Cells. Angew Chem Int Ed Engl. 2025 Oct 17:e202514788.