EGFR-TK-IN-6
EGFR-TK-IN-6 is an EGFR-TK inhibitor (IC50 = 0.65 μM) . EGFR-TK-IN-6 has anti proliferative activity against MCF-7 cells (IC50 = 37.7 μM) . EGFR-TK-IN-6 has low toxicity to normal cells. EGFR-TK-IN-6 can be used for cancer research[1].
Product Specifications
UNSPSC
12352005
Target
EGFR; Tyrosinase
Related Pathways
JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C1NC(C([C@@H](NCC)C2=CC=CC=C2)=C(N)N1)=O
Molecular Formula
C13H16N4O2
Molecular Weight
260.29
References & Citations
[1]Shehta W, et al. Synthesis, in silico and in vitro studies of aminopyrimidine hybrids as EGFR TK inhibitors and anti-proliferative agents. RSC Adv. 2025 Oct 6;15 (44) :36895-36906.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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