PLK4-IN-6

PLK4-IN-6 is an PLK4 inhibitor (IC50 IC50 = 0.948 μM), MCF-7 (IC50 = 0.979 μM), H460 (IC50 = 1.679 μM) cells. PLK4-IN-6 can significantly induce cell apoptosis and block the cell cycle. PLK4-IN-6 can be used for research on various types of cancer[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Polo-like Kinase (PLK)

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

CCN(C1=CC=CC=C1)C(CSC2=CC3=C(C(/C=C/C4=CC=CN=C4)=NN3)C=C2)=O

Molecular Formula

C24H22N4OS

Molecular Weight

414.52

References & Citations

[1]Alsehli M, et al. Click synthesis of some novel benzo[d]thiazole-1,2,3-triazole hybrid compounds with benzamide and/or benzoate tethers as EGFR-dependent signaling inhibitors against breast cancer. RSC Med Chem. 2025 Sep 2.