EGFR-IN-184
EGFR-IN-184 is an EGFR inhibitor (IC50 = 65.6 nM) . EGFR-IN-184 has anti proliferative activity against various tumor cells, such as T47D (IC50 = 15 μM), PC3 (IC50 = 55 μM), HCT116 (IC50 = 36 μM) cells. EGFR-IN-184 can significantly induce cell apoptosis and block the cell cycle. EGFR-IN-184 can be used for research on various types of cancer[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; EGFR
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
CC1=CC2=C(N=C(S2)NC(CN3C=C(N=N3)COC(C4=CC=C(C=C4)Cl)=O)=O)C=C1
Molecular Formula
C20H16ClN5O3S
Molecular Weight
441.89
References & Citations
[1]Alsehli M, et al. Click synthesis of some novel benzo[d]thiazole-1,2,3-triazole hybrid compounds with benzamide and/or benzoate tethers as EGFR-dependent signaling inhibitors against breast cancer. RSC Med Chem. 2025 Sep 2.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC741081-500 1x 500 µL
CD45RO (190-2F2.5), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC470669-500 1x 500 µL
P27 / KIP1 (SX53G8), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC040837-500 1x 500 µL
Ep-CAM / CD326 (EGP40/837), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC740957-500 1x 500 µL
Histone H1 (HH1/957), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details