EGFR-IN-184

EGFR-IN-184 is an EGFR inhibitor (IC50 = 65.6 nM) . EGFR-IN-184 has anti proliferative activity against various tumor cells, such as T47D (IC50 = 15 μM), PC3 (IC50 = 55 μM), HCT116 (IC50 = 36 μM) cells. EGFR-IN-184 can significantly induce cell apoptosis and block the cell cycle. EGFR-IN-184 can be used for research on various types of cancer[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; EGFR

Related Pathways

Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

CC1=CC2=C(N=C(S2)NC(CN3C=C(N=N3)COC(C4=CC=C(C=C4)Cl)=O)=O)C=C1

Molecular Formula

C20H16ClN5O3S

Molecular Weight

441.89

References & Citations

[1]Alsehli M, et al. Click synthesis of some novel benzo[d]thiazole-1,2,3-triazole hybrid compounds with benzamide and/or benzoate tethers as EGFR-dependent signaling inhibitors against breast cancer. RSC Med Chem. 2025 Sep 2.