EGFR-IN-185
EGFR-IN-185 is a EGFR inhibitor. EGFR-IN-185 exhibits potent activity against non-small cell lung cancer (NSCLC) cells harboring EGFR mutations. EGFR-IN-185 inhibits colony formation and migration, induces G0/G1 arrest, and promots apoptosis, which are associated with the suppression of EGFR and AKT phosphorylation. EGFR-IN-185 can be used for the research of NSCLC[1].
Product Specifications
UNSPSC
12352005
Target
Akt; Apoptosis; EGFR
Related Pathways
Apoptosis; JAK/STAT Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C1C2=CC(OCC3=CC=C(C4=CC=CC=C4)C=C3)=CC=C2NC5=C(C=C(F)C=C5)N1CCN(C)C
Molecular Formula
C30H28FN3O2
Molecular Weight
481.56
References & Citations
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-179143/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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