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EGFR-IN-185

EGFR-IN-185 is a  EGFR  inhibitor. EGFR-IN-185 exhibits potent activity against non-small cell lung cancer (NSCLC) cells harboring EGFR mutations.  EGFR-IN-185 inhibits colony formation and migration,   induces G0/G1 arrest, and promots apoptosis, which are associated with the suppression of EGFR and AKT phosphorylation.  EGFR-IN-185 can be used for the research of    NSCLC[1].

Product Specifications

UNSPSC

12352005

Target

Akt; Apoptosis; EGFR

Related Pathways

Apoptosis; JAK/STAT Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=C1C2=CC(OCC3=CC=C(C4=CC=CC=C4)C=C3)=CC=C2NC5=C(C=C(F)C=C5)N1CCN(C)C

Molecular Formula

C30H28FN3O2

Molecular Weight

481.56

References & Citations

[1]Jin C, et al. Design, synthesis and structure-activity relationship analysis of dibenzodiazepinone derivatives against Osimertinib resistant NSCLC. RSC Med Chem. Published online October 16, 2025.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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