HDB-1

HDB-1 is a selective inhibitor of the P2Y14 receptor (P2Y14R) with an IC50 of 26 pM. HDB-1 shows no significant inhibition on P2Y1R, P2Y2R, P2Y4R, P2Y6R, and P2Y12R. HDB-1 blocks the activation of hepatic stellate cells (HSC) by inhibiting the PKA/Raf1/MEK/ERK signaling pathway mediated by P2Y14R, thereby alleviating the core pathological process of liver fibrosis. HDB-1 can be used for the study of liver fibrosis[1].

Product Specifications

CAS Number

[3021527-82-9]

UNSPSC

12352005

Target

ERK; MEK; P2Y Receptor; PKA; Raf

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt; TGF-beta/Smad

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

CC1=CC=C(C=C1)NC2=C(C(C2=O)=O)NC3=CC=C4N=COC4=C3

Molecular Formula

C18H13N3O3

Molecular Weight

319.31

References & Citations

[1]Li C, et al. Discovery of Novel P2Y14R Inhibitors for Ameliorating Liver Fibrosis by Suppressing Hepatic Stellate Cell Activation. J Med Chem. 2025 Nov 13;68 (21) :23277-23299.