TN-783
TN-783 is an orally active, brain-penetrant NLRP3 (IC50 = 19.3 nM) inhibitor. TN-783 enhances the effects of the GLP-1 receptor agonist semaglutide. TN-783 requires sustained targeted action, not permanent metabolic remodeling. TN-783 can be used for the study of obesity[1].
Product Specifications
CAS Number
[2771021-30-6]
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Related Pathways
Immunology/Inflammation
Field of Research
Metabolic Disease; Inflammation/Immunology
Smiles
O=C(NC1=NC=C(C=N1)F)CN2C[C@H](C3=C(C2=O)C=CC(I)=C3)C(F)(F)F
Molecular Formula
C16H11F4IN4O2
Molecular Weight
494.18
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NLRP3
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